CUROSURF®
(poractant alfa) intratracheal suspension
Frequently Asked Questions
According to Section 2.3 [Preparation of the CUROSURF Suspension] of the FDA-approved prescribing information for CUROSURF (poractant alfa), unopened, unused vials of CUROSURF suspension that have warmed to room temperature can be returned to refrigerated storage within 24 hours for future use. Do not warm to room temperature and return to refrigerated storage more than once. Protect from light.
As stated in Section 2.1 [Important Administration Instructions] of the FDA-approved prescribing information for CUROSURF (poractant alfa), before administering CUROSURF, assure proper placement and patency of the endotracheal tube. At the discretion of the clinician, the endotracheal tube may be suctioned before administering CUROSURF. Allow the infant to stabilize before proceeding with dosing.
According to Section 2.4 [Administration] of the FDA-approved prescribing information for CUROSURF® (poractant alfa), if a 5 French end-hole catheter is being utilized for endotracheal tube instillation, attach the 5 French end-hole catheter of appropriate length to position the catheter tip proximal to the distal portion of the endotracheal tube, to the syringe. Fill the catheter with CUROSURF suspension. Discard excess CUROSURF through the catheter so that only the dose to be given remains in the syringe. If the secondary lumen of a dual lumen endotracheal tube is being used for endotracheal tube instillation, slowly withdraw the entire contents of the vial of CUROSURF suspension into a 3 or 5 mL plastic syringe through a large-gauge needle (e.g., at least 20 gauge). Do not attach 5 French end-hole catheter. Remove the needle and discard excess CUROSURF so that only the dose to be given remains in the syringe.